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despair
US
UK
noun
The despair of the prisoners was evident in their ravaged faces
hopelessness
desperation
discouragement
disheartenment
despondency
dejection
depression
gloom
gloominess
misery
melancholy
wretchedness
distress
miserableness
anguish
resignation
verb
We despaired of ever seeing our children again
give
up
or
lose
hope
surrender
quit